Chang Gung University
Department of Physiology and Pharmacology
內分泌與代謝生理實驗室
Peer-reviewed Publications
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Chiang, Y-T., Wu, Y-Y., Lin, Y-C., Huang, Y-Y., and Lu, J-C.*, (2023) Cyclodextrin-mediated cholesterol depletion induces adiponectin secretion in 3T3-L1 adipocytes, International Journal of Molecular Sciences, 24(19):14718. (*correspondence)
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Wang, H-L., Cheng, Y-C., Yeh, T-H., Liu, H-F., Weng, Y-H., Shen, R-S., Chen, Y-C., Lu, J-C., Hwang, T-L., Wei, K-C., Liu, Y-C., Wang, Y-T., Hsu, C-C., Chiu, T-J., and Chiu, C-C., (2023) HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson’s disease, Biochemical Pharmacology, 212:115524.
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Chiu, C-C., Weng, Y-H., Yeh, T-H., Lu, J-C., Shen, W-S., Li, A.H., Chen, Y-L., Wei, K-C., and Wang, H-L.*, (2023) Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein, Mol. Neurobiol. 60(5):2706-2728.
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Chen, C-F., Wo, R.R., Huang, C-T., Cheng, T-L., Lu, J-C., and Wang, C-T.* (2022) Phosphorylation of cysteine string protein-a regulates the frequency of cholinergic waves via starburst amacrine cells, Visual Neuroscience, 39:E003.
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Lu, J-C.*, Lu, C-Y., and Wu, Y-Y., (2021) THRAP3 depletion reduces PPARγ mRNA and anti-inflammatory action in 3T3-L1 adipocytes, Journal of Molecular Endocrinology, 67(3): 149-159. (*correspondence)
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Yang, H-J., Chen, P-C., Huang, C-T., Cheng, T-L., Hsu, S-P., Chen, C-Y., Lu, J-C.*, and Wang, C-T.*, (2021) The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release, Journal of Neuroscience, 41(13):2828-2841. (*correspondence)
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Hsiao, Y-T., Shu, W-C., Chen, P-C., Yang, H-J., Chen, H-Y., Hsu, S-P., Huang, Y-T., Yang, C-C., Chen, Y-J., Yu, N-Y., Liou, S-Y., Chaing, N., Huang, C-T., Cheng, T-L., Cheung, L-Y., Lin, Y-C., Lu, J-C.*, and Wang, C-T.* (2019) Presynaptic SNAP-25 regulates retinal waves and retinogeniculate projection via phosphorylation, Proc. Natl. Acad. Sci. USA, 116(8): 3262-3267. (*correspondence)
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Shih, C-T., Chang, Y-F., Chen, Y-T., Ma, C-P., Chen, H-W., Yang, C-C., Lu, J-C., Tsai, Y-S., Chen, H-C., and Tan, B. (2017) The PPARγ-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence, Aging Cell, 16(4): 797-813.
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Lu, J-C.*, Chiang, Y-T., Lin, Y-C., Chang, Y-T., Lu, C-Y., Chen, T-Y., and Yeh, C-S. (2016) Disruption of lipid raft function increases expression and secretion of monocyte chemoattractant protein-1 in 3T3-L1 adipocytes, PLoS One, 11(12):e0169005. (*correspondence)
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Chiang, N., Hsiao, Y-T., Yang, H-J., Lin, Y-C., Lu, J-C.*, and Wang, C-T.* (2014) Phosphomimetic mutation of cysteine string protein-α increases the rate of calcium-dependent exocytosis by modulating fusion pore dynamics in PC12 cells, PLoS One, 9(6): e99180. (*correspondence)
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Huang, C-Y., Chen, Y-L., Li, A-H., Lu, J-C., and Wang, H-L. (2014) Monocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons, Journal of Neuroinflammation, 11(1): 7.
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Huang, P-C., Hsiao, Y-T., Kao, S-Y., Chen, C-F., Chen, Y-C., Chiang, C-W., Lee, C-F., Lu, J-C., Chern, Y., and Wang, C-T. (2014) Adenosine A2A receptor up-regulates retinal wave frequency via starburst amacrine cells in the developing rat retina, PLoS One, 9(4): e95090.
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Lu, J-C., Hsiao, Y-T., Chiang, C-W., and Wang, C-T. (2014) GABAA receptor- mediated tonic depolarization in developing neural circuits, Molecular Neurobiology, 49:702- 723.
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Lu, J-C.*, Chang, Y-T., Wang, C-T., Lin, Y-C., Lin, C-K., Wu, Z-S. (2013) Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor alpha-induced lipolysis in 3T3-L1 adipocytes, PLoS One, 8(8): e71517. (*correspondence)
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Chiang, C-W., Chen, Y-C., Lu, J-C., Hsiao, Y-T., Chang, C-W., Huang, P-C., Chang, Y-T., Chang, P. Y., Wang, C-T. (2012) Synaptotagmin I regulates patterned spontaneous activity in the developing rat retina via calcium binding to the C2AB domains, PLoS One, 7(10): e47465.
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Kao, D-J., Li, A.H., Chen, J-C., Luo, R-S., Chen, Y-L., Lu, J-C., Wang, H-L. (2012) CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons, Journal of Neuroinflammation, 9(1):189.
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Piazza, T.M., Lu, J-C., Carver, K.C., and Schuler, L.A. (2009) SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells, Molecular Endocrinology, 23(2): 202-212.
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Saberi, M., Woods, N-B., de Luca, C., Schenk, S., Lu, J-C., Bandyopadhyay, G., Verma, I.M., and Olefsky, J.M. (2009) Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice, Cell Metababolism, 10(5): 419-429.
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Yoshizaki, T., Milne, J.C., Imamura, T., Schenk, S., Sonoda, N., Babendure, J.L., Lu, J-C., Smith, J.J., Jirousek, M.R., and Olefsky, J.M. (2009) SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes, Molecular and Cellular Biology, 29(5):1363-1374.
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Sonoda, N., Imamura, T., Yoshizaki, T., Babendure, J.L., Lu, J-C., and Olefsky, J.M. (2008) Beta-Arrestin-1 mediates glucagons-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells, Proc. Natl. Acad. Sci. USA, 105(18): 6614-6619.
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Kawamata, Y., Imamura, T., Babendure, J.L., Lu, J-C., Yoshizaki, T., and Olefsky, J.M. (2007) Tumor necrosis factor receptor-1 can function through a Galpha q/11/beta-arrestin-1 signaling complex. Journal of Biological Chemistry, 282(39): 28549-28556.
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Yoshizaki, T., Imamura, T., Babendure, J., Lu, J-C., Sonoda, N., and Olefsky, J.M. (2007) Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Molecular and Cellular Biology 27(14): 5172-5183.
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Lu, J-C., Piazza, T.M., and Schuler, L.A. (2005) Proteasomes mediate prolactin-induced receptor downregulation and fragment generation in breast cancer, Journal of Biological Chemistry, 280 (40):33909-33916.
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Usui, I., Imamura, T., Babendure, J.L., Satoh, H., Lu, J-C., Hupfeld, C.J., and Olefsky, J.M. (2005) G Protein-coupled Receptor Kinase 2 (GRK2) mediates endothelin-1- induced insulin resistance via the inhibition of both Galpha q/11 and IRS-1 pathways in 3T3-L1 adipocytes. Molecular Endocrinology, 19(11): 2760-2768.
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Huang J., Imamura T., Babendure J.L., Lu J-C., and Olefsky J.M. (2005) Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. Journal of Biological Chemistry 280 (51): 42300-42306.
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Wang, C-T., Lu, J-C., Bai, J., Chang, P.Y., Martin, T.F., Chapman, E.R., and Jackson, M.B. (2003) Different domains of synaptotagmin control the choice between kiss-and-run and full fusion, Nature, 424 (6951): 943-947.
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Lu, J-C., Scott, P., Strous, G.J., and Schuler, L.A. (2002) Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways, Molecular Endocrinology, 16 (11): 2515-2527.
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Schuler, L.A., Lu, J-C., and Brockman, J.L. (2001) Prolactin receptor heterogeneity: processing and signaling of the long and short isoforms during development. Biochemical Society Transactions, 29 (Pt2): 52-56.
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Hsu, L-C., Hu, M-C., Cheng, H-C., Lu, J-C., and Chung, B-c. (1993) The N-terminal hydrophobic domain of P450c21 is required for membrane insertion and enzyme stability, Journal of Biological Chemistry 268 (20): 14682-14686.